Classification of electroencephalogram (EEG) and electrocorticogram (ECoG) signals obtained during motor imagery (MI) has substantial application potential, including for communication assistance and rehabilitation support for patients with motor impairments. These signals remain inherently susceptible to physiological artifacts (e.g., eye blinking, swallowing), which pose persistent challenges. Although Transformer-based approaches for classifying EEG and ECoG signals have been widely adopted, they often struggle to capture fine-grained dependencies within them. To overcome these limitations, we propose Cortical-SSM, a novel architecture that extends deep state space models to capture integrated dependencies of EEG and ECoG signals across temporal, spatial, and frequency domains. We validated our method across three benchmarks: 1) two large-scale public MI EEG datasets containing more than 50 subjects, and 2) a clinical MI ECoG dataset recorded from a patient with amyotrophic lateral sclerosis. Our method outperformed baseline methods on the three benchmarks. Furthermore, visual explanations derived from our model indicate that it effectively captures neurophysiologically relevant regions of both EEG and ECoG signals.

In the conventional approaches for supervised parametric learning, relations between data and target variables are provided through training sets consisting of pairs of corresponded data and target variables. In this work, we describe a new learning scheme for parametric learning, in which the target variables y can be modeled with a prior model p(y) and the relations between data and target variables are estimated with p(y) and a set of uncorresponded data X in training.

Motor impairments, frequently caused by neurological incidents like strokes or traumatic brain injuries, present substantial obstacles in rehabilitation therapy. This research aims to elevate the field by optimizing motor imagery classification algorithms within Brain-Computer Interfaces (BCIs). By improving the efficiency of BCIs, we offer a novel approach that holds significant promise for enhancing motor rehabilitation outcomes. Utilizing unsupervised techniques for dimensionality reduction, namely Uniform Manifold Approximation and Projection (UMAP) coupled with K-Nearest Neighbors (KNN), we evaluate the necessity of employing supervised methods such as Long Short-Term Memory (LSTM) and Convolutional Neural Networks (CNNs) for classification tasks. Importantly, participants who exhibited high KNN scores following UMAP dimensionality reduction also achieved high accuracy in supervised deep learning (DL) models. Due to individualized model requirements and massive neural training data, dimensionality reduction becomes an effective preprocessing step that minimizes the need for extensive data labeling and supervised deep learning techniques. This approach has significant implications not only for targeted therapies in motor dysfunction but also for addressing regulatory, safety, and reliability concerns in the rapidly evolving BCI field.

Brain-computer interfaces are being explored for a wide variety of therapeutic applications. Typically, this involves measuring and analyzing continuous-time electrical brain activity via techniques such as electrocorticogram (ECoG) or electroencephalography (EEG) to drive external devices. However, due to the inherent noise and variability in the measurements, the analysis of these signals is challenging and requires offline processing with significant computational resources. In this paper, we propose a simple yet efficient machine learning-based approach for the exemplary problem of hand gesture classification based on brain signals. We use a hybrid machine learning approach that uses a convolutional spiking neural network employing a bio-inspired event-driven synaptic plasticity rule for unsupervised feature learning of the measured analog signals encoded in the spike domain. We demonstrate that this approach generalizes to different subjects with both EEG and ECoG data and achieves superior accuracy in the range of 92.74-97.07% in identifying different hand gesture classes and motor imagery tasks.

Several motor related Brain Computer Interfaces (BCIs) have been developed over the years that use activity decoded from the contralateral hemisphere to operate devices. Many recent studies have also talked about the importance of ipsilateral activity in planning of motor movements. For successful upper limb BCIs, it is important to decode finger movements from brain activity. This study uses ipsilateral cortical signals from humans (using ECoG) to decode finger movements. We demonstrate, for the first time, successful finger movement detection using machine learning algorithms.

In brain signal processing, deep learning (DL) models have become commonly used. However, the performance gain from using end-to-end DL models compared to conventional ML approaches is usually significant but moderate, typically at the cost of increased computational load and deteriorated explainability. The core idea behind deep learning approaches is scaling the performance with bigger datasets. However, brain signals are temporal data with a low signal-to-noise ratio, uncertain labels, and nonstationary data in time. Those factors may influence the training process and slow down the models' performance improvement. These factors' influence may differ for end-to-end DL model and one using hand-crafted features. As not studied before, this paper compares models that use raw ECoG signal and time-frequency features for BCI motor imagery decoding. We investigate whether the current dataset size is a stronger limitation for any models. Finally, obtained filters were compared to identify differences between hand-crafted features and optimized with backpropagation. To compare the effectiveness of both strategies, we used a multilayer perceptron and a mix of convolutional and LSTM layers that were already proved effective in this task. The analysis was performed on the long-term clinical trial database (almost 600 minutes of recordings) of a tetraplegic patient executing motor imagery tasks for 3D hand translation. For a given dataset, the results showed that end-to-end training might not be significantly better than the hand-crafted features-based model. The performance gap is reduced with bigger datasets, but considering the increased computational load, end-to-end training may not be profitable for this application.

The Partial Least Square Regression (PLSR) exhibits admirable competence for predicting continuous variables from inter-correlated brain recordings in the brain-computer interface. However, PLSR is in essence formulated based on the least square criterion, thus, being non-robust with respect to noises. The aim of this study is to propose a new robust implementation for PLSR. To this end, the maximum correntropy criterion (MCC) is used to propose a new robust variant of PLSR, called as Partial Maximum Correntropy Regression (PMCR). The half-quadratic optimization is utilized to calculate the robust projectors for the dimensionality reduction, and the regression coefficients are optimized by a fixed-point approach. We evaluate the proposed PMCR with a synthetic example and the public Neurotycho electrocorticography (ECoG) datasets. The extensive experimental results demonstrate that, the proposed PMCR can achieve better prediction performance than the conventional PLSR and existing variants with three different performance indicators in high-dimensional and noisy regression tasks. PMCR can suppress the performance degradation caused by the adverse noise, ameliorating the decoding robustness of the brain-computer interface.

Several motor related Brain Computer Interfaces (BCIs) have been developed over the years that use activity decoded from the contralateral hemisphere to operate devices. Many recent studies have also talked about the importance of ipsilateral activity in planning of motor movements. For successful upper limb BCIs, it is important to decode finger movements from brain activity. This study uses ipsilateral cortical signals from humans (using ECoG) to decode finger movements. We demonstrate, for the first time, successful finger movement detection using machine learning algorithms.

Abstract--The superior temporal gyrus (STG) region of cortex critically contributes to speech recognition. In this work, we show that a proposed deep network inspired by WaveNet, trained with limited available data, is able to reconstruct speech stimuli from STG intracranial recordings. We further investigate the impulse response of the fitted model for each recording electrode and observe phoneme level temporospectral tuning properties in some recorded area. This discovery is consistent with previous studies implicating the posterior STG (pSTG) in a phonetic representation of speech and provides detailed acoustic features that certain electrode sites possibly extract during speech recognition. Research studies on the superior temporal gyrus (STG) cortex area have shown that this area plays an important role in words and sentence recognition on a phonetic and prelexical stage [1]-[9].

Positive definite operator-valued kernels generalize the well-known notion of reproducing kernels, and are naturally adapted to multi-output learning situations. This paper addresses the problem of learning a finite linear combination of infinite-dimensional operator-valued kernels which are suitable for extending functional data analysis methods to nonlinear contexts. We study this problem in the case of kernel ridge regression for functional responses with an lr-norm constraint on the combination coefficients. The resulting optimization problem is more involved than those of multiple scalar-valued kernel learning since operator-valued kernels pose more technical and theoretical issues. We propose a multiple operator-valued kernel learning algorithm based on solving a system of linear operator equations by using a block coordinate-descent procedure. We experimentally validate our approach on a functional regression task in the context of finger movement prediction in brain-computer interfaces.